Compound | Inhibition of tubulin polymerization | Inhibition of colchicine binding | Inhibition of MCF-7 growth |
---|---|---|---|
IC50 ± SD (μm) | % inhibition ± SD | IC50 ± SD (μm) | |
Curacin A | 0.72 ± 0.2 | 94 ± 2 | 0.038 ± 0.01 |
9 | 5.5 ± 0.7 | 3 ± 5 (50 ± 6) | >13-a |
10 | 0.74 ± 0.01 | 74 ± 11 | 0.30 ± 0.07 |
11 | 1.5 ± 0.4 | 9 ± 8 (32 ± 2) | 4.2 ± 2 |
In the colchicine binding assay, inhibitor concentration was 5.0 μm, except for the values in parentheses, where the inhibitor concentration was 50 μm.
↵3-a Insufficient sample to test at higher concentrations.
SD, standard deviation.