Table 6
Partial structures
| Compound | Inhibition of tubulin polymerization | Inhibition of colchicine binding | Inhibition of MCF-7 growth |
|---|---|---|---|
| IC50 ± SD (μm) | % inhibition ± SD | IC50 ± SD (μm) | |
| Curacin A | 0.72 ± 0.2 | 94 ± 2 | 0.038 ± 0.01 |
| 22 | >80 | 06-a (5 ± 4) | >10 |
| 23 | 3.3 ± 0.8 | 12 ± 15 (67 ± 11) | 5.2 ± 3 |
In the colchicine binding assay, inhibitor concentration was 5.0 μm, except for the values in parentheses, where the inhibitor concentration was 0 μm.
-
↵6-a The same value was obtained in three experiments.