Table 3

Activation of wild-type and mutant receptors by GABA

CombinationEC50Hill coefficientOocytes
μm n
ρ11.16  ± 0.262.36  ± 0.486
ρ1L301F0.85  ± 0.141.26  ± 0.216
ρ1L301I0.55  ± 0.231.13  ± 0.505
ρ1L301V2.27  ± 0.890.87  ± 0.156
ρ1L301Y1.81  ± 0.591.01  ± 0.306

Parameters are mean ± standard deviation.