G protein coupling specificity of mGlu receptors from the different groups
Group | Gαq | Gαqi | Gαqo | Gαqz | Gα15 | Gα16 |
---|---|---|---|---|---|---|
I | + | + | + | + | ? | − |
II | − | + | + | − | + | + |
III | − | + | + | + | + | − |
+, Coupling (i.e., interaction and activation) to the G protein; −, lack of coupling to the G protein studied.