Agonists EC50 values for DmGluA, mGlu1, and the chimeric mGlu1a/D-4 receptors
| Agonist | EC50 | ||
|---|---|---|---|
| DmGluA | mGlu1 | mGlu1a/D-4 | |
| μm | |||
| Glutamate | 1.25 ± 0.07 | 0.9 ± 0.4 | 5.9 ± 3.0 |
| l-Quisqualate | 37 ± 7 | 0.03 ± 0.01 | 0.14 ± 0.03 |
| Ibotenate | 38 ± 29 | 1.9 ± 0.6 | 7.0 ± 1.9 |
| 1S, 3S-ACPD | 29 ± 8 | 87 ± 49 | 236 ± 124 |
| 1S, 3R-ACPD | 67 ± 1 | 4.7 ± 1.4 | 12.3 ± 2.3 |
| L-CCG-I | 5.8 ± 5 | 1.87 ± 0.06 | 5.7 ± 0.6 |
| DHPG | >10002-a | 5.7 ± 2.5 | 7.5 ± 0.1 |
EC50 are determined as described in the text and are the mean ± standard error of at least two independent experiments performed in triplicate.
↵2-a The molecule at 1 mm induced a response <50% of the maximal effect of glutamate.