Table 2

Pharmacological properties of β₁-F350A,F351L mutant receptors

Drug	¹²⁵I-CYP bindingK_i	cAMP accumulation
Drug	¹²⁵I-CYP bindingK_i	pEC₅₀	Intrinsic activity
	nm	nm
ISO	6.7 ± 0.1	8.2 ± 0.3	1.0
NE	5.4 ± 0.1	6.9 ± 0.1	1.07 ± 0.07
DOB	5.3 ± 0.1	6.3 ± 0.2	0.68 ± 0.11
BRL	6.6 ± 0.2*	7.3 ± 0.5*	0.39 ± 0.06
CL	5.7 ± 0.2*	6.7 ± 0.2*	0.53 ± 0.07*

Values are means ± SE for four to five experiments.
* Significantly different from β₁-AR.