Amino acid identities of MLP-1 and MLP-2 with related ABC transporters
| Domain | Entire length | Upstream of ABC-1 | ABC-1 | Between ABC-1 and 2 | ABC-2 | Downstream of ABC-2 | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Amino acids | 1–1502 | 1–643 | 644–792 | 793–1280 | 1281–1437 | 1438–1502 | |||||||
| MLP-1 | |||||||||||||
| hMRP | 1531 aa | 42.8 | 35.5 | 58.4 | 41.6 | 62.2 | 47.6 | ||||||
| Rat cMOAT | 1541 aa | 38.3 | 25.2 | 51.0 | 34.2 | 57.1 | 42.9 | ||||||
| Rat MLP-2 | 1523 aa | 40.2 | 35.7 | 57.7 | 35.0 | 59.0 | 50.0 | ||||||
| Rabbit EBCR | 1565 aa | 38.6 | 26.7 | 51.0 | 33.7 | 59.0 | 41.3 | ||||||
| Rat SUR | 1582 aa | 33.0 | 21.9 | 39.1 | 26.3 | 51.3 | 36.2 | ||||||
| YCF1 | 1515 aa | 32.7 | 26.3 | 48.3 | 28.5 | 51.6 | 46.9 | ||||||
| Human MRP31-a | 485 aa | 41.2 | 56.4 | 53.1 | |||||||||
| Human MRP41-a | 126 aa | 58.6 | 39.7 | ||||||||||
| Human MRP51-a | 222 aa | 54.7 | 39.7 | ||||||||||
| Amino acids | 1–1523 | 1–642 | 643–791 | 792–1301 | 1302–1458 | 1459–1523 | |
|---|---|---|---|---|---|---|---|
| MLP-2 | |||||||
| hMRP | 1531 aa | 55.7 | 52.4 | 67.8 | 48.7 | 73.2 | 73.4 |
| Rat cMOAT | 1541 aa | 45.7 | 35.7 | 66.4 | 43.3 | 71.8 | 56.2 |
| Rabbit EBCR | 1565 aa | 45.2 | 36.7 | 63.1 | 42.6 | 68.8 | 53.1 |
| Rat SUR | 1582 aa | 36.7 | 24.0 | 44.8 | 30.3 | 51.6 | 38.6 |
| YCF1 | 1515 aa | 38.0 | 29.4 | 51.0 | 35.3 | 73.1 | 58.5 |
| Human MRP31-a | 485 aa | 79.1 | 84.1 | 89.2 | |||
| Human MRP41-a | 126 aa | 51.6 | 52.5 | ||||
| Human MRP51-a | 222 aa | 55.7 | 54.2 | ||||
EBCR, epithelial basolateral chloride conductance regulator; SUR, sulfonylurea receptor; YCF1, yeast cadmium factor; ABC-1, amino-terminal ABC; ABC-2, carboxyl-terminal ABC.
↵1-a Partial sequences were reported by Kool et al., 1997.