Effect of [3-R]L-364,373 (R-L3) on action potential (AP) parameters of guinea pig isolated ventricular myocytes
| AP parameter | Control | R-L3 | ANOVA p | ||
|---|---|---|---|---|---|
| 0.1 | 1 | 10 | |||
| μm | |||||
| APD90 (msec) | 199.7 ± 7.6 | 193.0 ± 6.8 | 170.6 ± 4.7 | 171.1 ± 8.3 | 0.012 |
| APD50 (msec) | 166.5 ± 7.7 | 160.9 ± 7.6 | 137.1 ± 5.0 | 124.4 ± 9.9 | 0.002 |
| APD@0 (msec) | 126.3 ± 9.8 | 119.1 ± 11.2 | 104.4 ± 7.4 | 90.1 ± 12.2 | 0.127 |
| APA (mV) | 121.1 ± 3.6 | 119.8 ± 4.5 | 120.6 ± 4.2 | 118.1 ± 6.5 | 0.994 |
| RMP (mV) | −88.25 ± 1.3 | −89.1 ± 1.4 | −86.9 ± 1.2 | −88.0 ± 1.4 | 0.844 |
| APA50ms (mV) | 111.6 ± 2.9 | 110.9 ± 3.6 | 109.0 ± 2.9 | 105.7 ± 5.0 | 0.783 |
| No. of cells | 10 | 8 | 10 | 7 | |
APD@0 - action potential duration at 0 mV.
Data are mean ± standard error.