Table 2

Competition of J-104,871 for FPP

ConcentrationIC50
FPPRas CAAX
μm nm
0.63.64.8
63.648
0.60.366.8

Mutual sets of two distinct concentrations of FPP and Ras CAAX (biotinylated KTSCVIM) were designed. The IC50 values of J-104,871 were determined as described in Experimental Procedures.