Table 4

Proportion of binding sites in the high affinity state (K H) for wild-type and mutant D2S receptors

AgonistD2SS193AS194AS197A
% KH
Dopamine37  ± 1334  ± 229  ± 542  ± 5
NPA (nm)37  ± 424  ± 325  ± 337  ± 2
DHX31  ± 60 0 39  ± 9
Quinpirole27  ± 438  ± 1125  ± 634  ± 8
7-OH-DPAT28  ± 627  ± 340  ± 525  ± 13

The proportion of high affinity sites was calculated from the values obtained for K H as described in Table 3.