Proportion of binding sites in the high affinity state (K H) for wild-type and mutant D2S receptors
| Agonist | D2S | S193A | S194A | S197A |
|---|---|---|---|---|
| % KH | ||||
| Dopamine | 37 ± 13 | 34 ± 2 | 29 ± 5 | 42 ± 5 |
| NPA (nm) | 37 ± 4 | 24 ± 3 | 25 ± 3 | 37 ± 2 |
| DHX | 31 ± 6 | 0 | 0 | 39 ± 9 |
| Quinpirole | 27 ± 4 | 38 ± 11 | 25 ± 6 | 34 ± 8 |
| 7-OH-DPAT | 28 ± 6 | 27 ± 3 | 40 ± 5 | 25 ± 13 |
The proportion of high affinity sites was calculated from the values obtained for K H as described in Table 3.