Table 1

Expression pattern of the UGT1A locus in gastric carcinoma and normal gastric mucosa

UGTGastric tissue (n = 14)TotalHepatic tissue (n = 16) normal
TumorNormal
UGT1A134416
UGT1A313316
UGT1A400016
UGT1A50000
UGT1A645516
UGT1A71312130
UGT1A80000
UGT1A900016
UGT1A101314140

Studied samples were collected as pairs of tumor tissue and surrounding healthy mucosa from the same organ. Total denotes presence of specific UGT1A transcripts in either tumor or normal sample of the individual patient. Polymorphic regulation of UGT1A1, UGT1A3, and UGT1A6 are noted in human gastric epithelium. In contrast, the analysis of a panel of 16 hepatic RNAs [as reported in Strassburg et al. (1997b)] displays no polymorphic UGT1A expression in human liver.