α4:β2 ratio | IC_{50} | n_{H} | E_{max} |
---|---|---|---|
μM | % of control | ||
9:1 | 0.20 ± 0.04^{2-d} | 0.75 ± 0.02 | 100 |
1:1 | 0.53 ± 0.09^{de} | 0.77 ± 0.13 | 100 |
1:1^{2-a} | 0.64 ± 0.15^{e} | 0.71 ± 0.04 | 100 |
1:9^{2-b} | 1.08 ± 0.75^{f} | 0.71 ± 0.17 | 67.6 ± 8.2 |
163 ± 37^{2-d} | 1.98 ± 0.93 | 32.4 ± 8.2 | |
1:9^{2-c} | 2.04 ± 0.29^{df} | 0.67 ± 0.03 | 100 |
Responses were evoked by superfusion with 300 μm ACh. For each experimental condition, three concentration-effect curves, each obtained from a different oocyte, were fitted, and the values represent mean ± standard deviation of the estimated parameters.
↵2-a Reduced receptor expression level.
↵2-b Two-component concentration-effect curve.
↵2-c Responses evoked by superfusion with 10 μmACh.
↵2-d Statistical significant difference (t test; p < 0.01) between all groups indicated.
No statistical significant difference (t test;^{e} p = 0.33, ^{f} p = 0.11).