Peptide1-a | Concentration | Positive corneas/ no. implanted | |
---|---|---|---|
Tested alone | Tested + bFGF | ||
μM | |||
d-Ser4-Mal II, 19-mer | 10 | 0 /3 | 0 /4 |
d-Ser5-Mal II, 19-mer | 1.0 | 1 /2 | 1 /5 |
d-IIe15-Mal II, 19-mer | 20 | 0 /3 | 0 /3 |
d-IIe15-Mal II, acetylated | 0.05 | 0 /3 | 0 /2 |
heptapeptide | 0.1 | 0 /3 | 1 /3 |
1.0 | 0 /3 | 0 /5 | |
20 | 0 /4 | 0 /2 | |
Buffer control | nd | 6 /6 |
Indicated peptide was incorporated into a hydron pellet, implanted into rat corneas, and neovascularization was assessed 7 days later. Vigorous, sustained ingrowth of vessels was scored as a positive angiogenic response. nd, not determined.
↵1-a See Table 2 for peptide structures.