Table 4

Suppression of corneal neovascularization by systemic treatment of mice with d-IIe15 Mal II peptides

Peptide Injected SystemicallyDoseCorneal responses
++/−% inhibited
mg/mouse/day
Ethylamide-capped heptapeptide0.224114
0.7512667
PBS vehicle900<0.2
  • Mouse corneas were implanted with pellets releasing bFGF and the animals were treated systemically with the indicated compound for 5 days, after which corneal angiogenesis was assessed. +, vigorous ingrowth to pellet; +/−, weak response with few vessels growing inward; −, no vessel ingrowth.