Table 1

IC50 values (nM) for peptides in competition for125I-labeled rat amylin binding to COS-7 cells cotransfected with 100 ng of hCTRI1− and 100 ng of RAMP (n = 3)

RAMP 1RAMP 3α-TSH Cells1-150
Competing peptide
 Rat amylin7.86  ± 4.496.35  ± 1.7010.5  ± 0.32
 Salmon CT0.309  ± 0.1440.206  ± 0.0040.37  ± 0.10
 Human CT447  ± 78862  ± 619N.D.
 Human CGRPα4.68  ± 3.04151  ± 481-160 5.95  ± 1.70
  • 1-150  From Perry et al., 1997.

  • 1-160P < .05 RAMP 1 versus RAMP 3 (n = 3).