IC50 values (nM) for peptides in competition for125I-labeled rat amylin binding to COS-7 cells cotransfected with 100 ng of hCTRI1− and 100 ng of RAMP (n = 3)
RAMP 1 | RAMP 3 | α-TSH Cells1-150 | |
---|---|---|---|
Competing peptide | |||
Rat amylin | 7.86 ± 4.49 | 6.35 ± 1.70 | 10.5 ± 0.32 |
Salmon CT | 0.309 ± 0.144 | 0.206 ± 0.004 | 0.37 ± 0.10 |
Human CT | 447 ± 78 | 862 ± 619 | N.D. |
Human CGRPα | 4.68 ± 3.04 | 151 ± 481-160 | 5.95 ± 1.70 |