IC50 values (M) for peptides in competition for125I-labeled salmon CT binding to COS-7 cells cotransfected with 100 ng of hCTRI1− and 100 ng of RAMP (n = 3)
| Receptor Alone | RAMP1 | RAMP2 | RAMP3 | |
|---|---|---|---|---|
| Competing peptide | ||||
| Rat amylin | 5.37 ± 2.84 × 10−7 | 1.72 ± 0.73 × 10−7 | 8.78 ± 1.96 × 10−8 | 1.96 ± 0.95 × 10−7 |
| Salmon CT | 9.33 ± 6.08 × 10−10 | 2.24 ± 0.30 × 10−10 | 1.34 ± 0.46 × 10−10 | 3.17 ± 0.35 × 10−10 |
| Human CT | 1.55 ± 0.23 × 10−8 | 2.95 ± 0.52 × 10−8 | 8.27 ± 1.57 × 10−9 | 1.97 ± 1.06 × 10−8 |
| Human CGRPα | >10−6 | >10−6 | >10−6 | 10−6 |