Table 1

Cytotoxicity of NSC 652287 in renal carcinoma cell lines from NCI Anticancer Drug Screen

Cell Line1-aGI50TGI1-bLC501-c
μM
A498 (Wt)0.017  ± 0.0030.035  ± 0.0100.144  ± 0.04
TK-10 (m)0.032  ± 0.0080.232  ± 0.116>100
ACHN (Wt)22.76  ± 13.0894.52  ± 5.47>100
UO-31 (Wt)41.71  ± 7.6188.58  ± 11.41>100

Cytotoxicity was assessed by the SRB assay at 48 h of drug exposure. Data were obtained from six to seven independent experiments. A full set of data including data for the other cell lines of the NCI Anticancer Screen are available at http://dtp. nci.nih.gov/.

    • ↵1-a p53 status indicated in parenthesis (Wt: wild-type p53; m: mutant p53) (O’Connor et al., 1997).

    • ↵1-b TGI, drug concentration required for total growth inhibition.

    • ↵1-c LC50, drug concentration required for 50% cell killing.