Table 1

Effectiveness of several compounds as inhibitors of P-glycoprotein- and Mrp2-mediated transport in killifish renal proximal tubules

Concentration Causing 50% Inhibition
CSAVerapamilLTC4SaquinavirRitonavir
μM
P-glycoprotein (NBDL-CSA)0.25–10>110.05
Mrp2 (FL-MTX)250–1000.320.05

Values were estimated from dose-response curves in Figs. 3 and 4 and from data of Schramm et al., 1995; Masereeuw et al., 1996; and Miller et al., unpublished observations.