Amino acid sequence motifs in renal organic anion transporter 1 homologs
| Gene (species) | % Identity with hOAT1 | Conserved cysteine residues | N-linked glycosylation consensus sites | Consensus sites | |||
|---|---|---|---|---|---|---|---|
| PKA | PKC | CKII | TK | ||||
| hOAT1/ROAT1 | 49 ,78, 105,128 | 39, 56 , 92 , 97,113 | Ser271 ,Ser278, | Ser325, Thr515, | Tyr536 | ||
| (human) | Thr284,Thr334, | Ser543 | |||||
| Ser521 | |||||||
| rROAT1/OAT1 | 88 | 49 , 78,105, 128 | 39, 56 , 92 , 97,113 | Ser271 ,Ser278, | Ser325, Thr515, | ||
| (rat) | Thr284,Thr334 | Ser544 | |||||
| mNKT (mROAT1) | 86 | 49 ,78, 99, 122 | 39, 56 , 86, 91,107 | Ser265 ,Ser272, | Ser319, Thr509, | ||
| (mouse) | Thr278,Thr328 | Ser538 | |||||
| fROAT | 49 | 49, 81, 117, 140 | 54, 95, 124 | Thr351, Ser409 | Thr13, Ser168, | Ser337, Thr527, | |
| (winter flounder) | Ser283, Ser290, | Ser543, | |||||
| Ser324, Ser536, | Thr549 | ||||||
| Ser543 | |||||||
Potential modification sites for transport proteins with the corresponding amino acid position numbers within their respective polypeptide chains. Boldface denotes positions conserved between homologs, underline denotes positions conserved within mammals, and italics denotes sites unique to hOAT1.