Table 1

Summary of agonist properties

AgonistEC50ImaxnHEPMRN
μM
ATP0.7  ± 0.11.00.719
2meSATP1.3  ± 0.31.01.31.99
ATPγS2.0  ± 0.50.61.12.96
α,β-meATP3.1  ± 0.60.60.84.46
ADP13  ± 3.30.80.918.610
CTP18.6  ± 3.70.31.526.510

EC50 was determined from a three-parameter (EC50,Imax, nH) curve fit to pooled data as described in Materials and Methods; estimates are expressed as mean ± S.D. EPMR, equipotent molar ratio and equals (EC50, test agonist)/(EC50, ATP). N, number of cells contributing to the pooled data for each agonist.