Agonist saturation analysis of Gi or Go at the CB1 or CB2 receptor
| CB1 versus Gi | CB1 versus Go | CB2 versus Gi | ||||
|---|---|---|---|---|---|---|
| Vmax (n = 5) | EC50 (n = 5) | Vmax (n = 4) | EC50 (n = 4) | Vmax (n = 4) | EC50 (n = 4) | |
| % | nM | % | nM | % | nM | |
| HU210 | 100 | 2.3 ± 0.3 | 100 | 3.1 ± 0.3 | 100 | 4.6 ± 0.7 |
| Δ9-THC | 56 ± 6** | 196 ± 13 | 64 ± 10** | 185 ± 28 | 42 ± 0.4** | 97 ± 29 |
| Anandamide | 92 ± 4 | 538 ± 54 | 71 ± 6*** | 776 ± 78 | 45 ± 2** | 1027 ± 94 |
| WIN55,212 | 102 ± 4 | 330 ± 53 | 72 ± 121-150 | 362 ± 93 | 65 ± 3** | 40 ± 4 |
Data are means ± S.E. for values obtained from nexperiments. All V max values are normalized to HU210 data.
↵1-150 p ≤ .05, ** p ≤ .01, *** p ≤ .001 by Students t test.