Table 1

Inhibitory effect of CGP64222 on the replication of several HIV strains in MT-4 cells

HIV StrainInhibition of Virus Replication IC501-aToxicity CC501-bSelectivity Index
μg/ml
IIIB 8.4>125>15
RF1.8>125>69
NDK2.4>125>52
MN2.5>125>50
RTMC11.9>125>10
HE8.4>125>15
ROD5.0>125>25
NL4.35.1>125>10
NL4.3DS5000 R 5.9>125>8
NL4.3AR177 R 14.5>125>4
NL4.3AMD2763 R >50>125
NL4.3AMD3100 R >50>125

Data are averages of two or three experiments, each performed in triplicate.

  • 1-a 50% inhibitory concentration. Anti-HIV activity was monitored by a tetrazolium-based viability assay in HIV-infected cells.

  • 1-b 50% cytotoxic concentration. Cytotoxicity was measured in parallel with the anti-HIV activity via a tetrazolium-based viability assay in mock-infected cells.