Table 2

Anti-HIV activity of CGP64222, SDF-1α, RANTES, and Ro5-3335 in U87.CD4 cells transfected with CXCR4 or CCR5

CompoundInhibition of Virus ReplicationToxicity CC50
Coreceptor HIV strainCXCR4 NL4.3CCR5 BaL
μg/ml
CGP642221.1>50>50
SDF-1α0.27>1>1
RANTES>10.61>1
Ro5-33350.51.85

Virus yield was monitored in the cell-free supernatant from U87.CD4 transfected cells 6 days after infection using a viral p24 antigen ELISA.