Table 3

Inhibitory effect of CGP64222 on the replication of M-tropic HIV-1 strains in PBLs

HIV-1 StrainInhibition of Virus Replication IC503-aToxicity CC503-a
μg/ml
BaL1.2>50
ADA0.7>50

Data are averages of two separate experiments.

  • 3-a Anti-HIV activity was monitored by quantification of p24 viral antigen production in the culture supernatant.

  • 3-b Cytotoxicity was measured in parallel by trypan blue exclusion.