Table 1

Transfer coefficients for [14C]dox, [14C]dox-d-penetratin, and [14C]dox-SynB1 uptake into rat brain. Data are presented as mean ± S.E.; n = 3–6. Perfusion time was 60 s and wash-out time was 30 s. Pretreatment with verapamil was carried out 5 min before perfusion at 1 mg/kg.

Kin
ControlVerapamil Pretreated
μl/s/g
Dox0.25 ± 0.090.36 ± 0.01
Dox-d-Penetratin2.31 ± 0.462.15 ± 0.34
Dox-SynB11.20 ± 0.171.31 ± 0.13