Table 2

The area under plasma and tissues concentration curve (AUC) values were calculated for both dox-SynB1 and free dox from the time of injection to the given time point. The ratio of AUC tissue/AUC plasma of free and vectorized dox is represented here.

Time (min)AUC Tissue/AUC Plasma
BrainHeartLungsLiverKidneys
doxdox-SynB1doxdox-SynB1doxdox-SynB1doxdox-SynB1doxdox-SynB1
10.0170.0440.90.3251.1650.3070.3110.3244.4141.511
50.0370.062.2860.5783.0390.5940.9740.5867.6753.291
150.0590.0695.0410.656.5030.8093.1090.74617.3414.183
300.0860.097.7870.6749.331.0025.9810.93425.2644.585
600.1360.10411.0720.67712.6041.1748.9671.22234.524.959
1800.2330.13218.7230.73422.3651.46312.341.87550.3655.45
4800.2950.15320.9590.76729.2631.79313.1642.49253.5885.924
12800.320.17517.630.76830.6832.86812.0853.26948.9846.136