Table 2

Cross-reactivity profile for GSTP1-1+/+ and GSTP1-1−/− MEF cells

DrugGSTP1-1+/+GSTP1-1−/−Resistance Ratio
TER28650.0  ± 10.082.5  ± 2.51.7
TER19954.0  ± 12.954.6  ± 12.11.0
Taxol0.1  ± 0.00.1  ± 0.01.0
Mitoxantrone0.7  ± 0.30.7  ± 0.21.0
Cisplatin26.3  ± 14.025.3  ± 16.01.0
Melphalan49.0  ± 9.052.6  ± 11.01.1
Doxorubicin0.4  ± 0.10.4  ± 0.11.0

Cell survival to other classes of chemotherapeutics was assessed 72 h after exposure to the agents. IC50 values are shown (μM).