Table 1

Effect of antagonists on mecamylamine-sensitive [3H]dopamine release from rat striatal slices stimulated with 25 μM AnTx-a

Antagonist Treatment[3H]Dopamine Release
% 25 μM AnTx-a control1-a
None100.0
α-Bgt (40 nM)60.2  ± 15.6  (n  = 8)
MLA (50 nM)68.7  ± 9.0  (n  = 7)
αCtx-MII (112 nM)70.9  ± 4.8  (n  = 4)
α-Bgt + DNQX (100 μM)61.1  ± 9.6  (n  = 5)
MLA + DNQX (100 μM)67.3  ± 11.9  (n  = 3)
α-Bgt + αCtx-MII27.4  ± 18.0  (n  = 5)1-150
MLA + αCtx-MII28.7  ± 2.5  (n  = 3)1-160

  • ↵1-a  Mecamylamine-sensitive [3H]dopamine release.

  • ↵1-150  P < .01, significantly different from response in the presence of α-Bgt alone.

  • ↵1-160  P < .01, significantly different from response in the presence of MLA alone (one-way ANOVA, Bonferroni'st test).