Table 1

Peak COX-2 mRNA responses expressed as fold induction over basal and inhibition by CsA

TreatmentnCOX-2 mRNA − CsA (Mean ± S.E.)COX-2 mRNA + CsA (Mean ± S.E.)% CsA Inhibition (Mean ± S.E.)
Ionomycin +PMA3184  ± 11028  ± 1167  ± 11
UTP572  ± 2635  ± 1246  ± 10
Angiotensin II481  ± 3426  ± 1166  ± 2
PDGF314  ± 35  ± 159  ± 11
Forskolin320  ± 921  ± 5No effect
IL-1β38  ± 310  ± 4No effect

Although there was interassay variability in the absolute fold induction, the percentage of inhibition by CsA within each replicate experiment is highly consistent.