Table 1

Percentage potentiation by 100 nM diazepam of currents induced by EC50 GABA concentration for wild type and the Cys-substitution mutants

MutantDiazepam-induced potentiationGABA EC501-a
% μM
Wild type26  ± 32.1  ± 1.3
Y294C73  ± 244.9  ± 1.6
F296C54  ± 161.4  ± 0.4
V297C21  ± 32.4  ± 0.6
F298C38  ± 1828  ± 4.0
S299C22  ± 24.5  ± 0.2
A300C39  ± 13.5  ± 0.5
L301C52  ± 3148  ± 15
I302C27  ± 151.9  ± 0.8
E303C37  ± 171.4  ± 0.3
  • 1-a  Data from Williams and Akabas (1999).