Summary of the effect on subsequent GABA-induced currents of pCMBS− application in the presence of various reagents
| Mutant | −GABA4-a | +GABA4-a | +Diazepam |
|---|---|---|---|
| WT | — | — | — |
| Y294C | ↓ | ↓ | ↓ |
| F296C | — | ↓ | ↑ |
| V297C | — | — | — |
| F298C | — | ↑ | ↑ |
| S299C | — | — | — |
| A300C | — | ↑ | — |
| L301C | — | ↑ | ↑ |
| I302C | — | — | — |
| E303C | — | ↓ | — |
—, no effect; ↑, potentiation of subsequent GABA-induced currents; ↓, inhibition of subsequent GABA-induced currents.
↵4-a Results in the presence and in the absence of GABA taken from Williams and Akabas (1999).