A1 agonist concentration-response parameters for inhibition of forskolin-stimulated (3 μM) [3H]cAMP accumulation in high and low expressing CHO-K1 cells transfected with the human adenosine A1 receptor
| Cell Line | Agonist | Inhibition of cAMP log IC50 | Extent of Maximal Response |
|---|---|---|---|
| M | % 3 μM forskolin control | ||
| CHOA1L | CPA | −7.54 ± 0.18 (8) | 33.1 ± 3.0 (8) |
| NECA | −6.94 ± 0.22 (6) | 26.6 ± 3.1 (6) | |
| R-PIA | −7.67 ± 0.09 (3) | 33.4 ± 0.7 (3) | |
| CHOA1H | CPA | −9.52 ± 0.14 (8) | 5.0 ± 2.7 (8) |
| NECA | −9.44 ± 0.02 (3) | 2.3 ± 1.9 (3) | |
| R-PIA | −10.06 ± 0.06 (3) | 2.7 ± 0.6 (3) |
Values represent means ± S.E.M. obtained from three to eight separate experiments (actual number given in parentheses).