Table 1

Summary of the equilibrium constants of the allosteric two-state model

ParameterDescriptionDefinition
K Association constant of A
L Receptor isomerization constant
M Association constant of B
αIntrinsic efficacy of A: ratio of affinity (and therefore selectivity) of A for R* and R
βIntrinsic efficacy of B: ratio of affinity of B for R* and R
γBinding cooperativity between A and B: ratio of affinity of A for BR and R or of B for AR and R
δActivation cooperativity between A and B: ratio of affinity of A for BR* and BR or of B for AR* and AR