Table 1

Summary of the equilibrium constants of the allosteric two-state model

ParameterDescriptionDefinition
K Association constant of A Embedded Image
L Receptor isomerization constant Embedded Image
M Association constant of B Embedded Image
αIntrinsic efficacy of A: ratio of affinity (and therefore selectivity) of A for R* and R Embedded Image
βIntrinsic efficacy of B: ratio of affinity of B for R* and R Embedded Image
γBinding cooperativity between A and B: ratio of affinity of A for BR and R or of B for AR and R Embedded Image
δActivation cooperativity between A and B: ratio of affinity of A for BR* and BR or of B for AR* and AR Embedded Image