Table 1

Summary of m values obtained from analysis of dissociation assays

Alcuronium (BBSS)Alcuroniumd-TubocurarineMethoctramineObidoximeTHATMB-8VerapamilUH-AH 37Gallamine
M1 >0.9N.D.0.88  ± 0.04>0.90.72  ± 0.03>0.9>0.9>0.90.76  ± 0.06>0.9
M2 >0.9>0.9>0.9>0.90.67  ± 0.06>0.9>0.9>0.90.88  ± 0.04>0.9
M3 0.86  ± 0.09N.D.>0.9>0.90.69  ± 0.08>0.9>0.9>0.90.73  ± 0.08>0.9
M4 >0.9N.D.>0.9>0.90.79  ± 0.02>0.9>0.9>0.9>0.9>0.9
M5 0.84  ± 0.10>0.9>0.90.79  ± 0.020.64  ± 0.03>0.90.86  ± 0.09>0.90.66  ± 0.120.82  ± 0.05
M2 >0.9>0.9>0.9>0.9N.D.>0.9>0.9>0.9>0.9>0.9
M5 0.74  ± 0.11>0.90.88  ± 0.060.67  ± 0.08N.D.>0.90.71  ± 0.100.81  ± 0.120.72  ± 0.140.75  ± 0.06
CR10.84  ± 0.09>0.90.88  ± 0.060.64  ± 0.11N.D.>0.9>0.90.79  ± 0.11>0.9>0.9
CR20.83  ± 0.06>0.90.86  ± 0.110.68  ± 0.06N.D.0.78  ± 0.100.74  ± 0.050.79  ± 0.09>0.9>0.9
CR3>0.9>0.90.84  ± 0.030.75  ± 0.06N.D.>0.9>0.9>0.9>0.9>0.9
CR40.69  ± 0.07>0.90.89  ± 0.060.77  ± 0.07N.D.>0.90.69  ± 0.080.82  ± 0.17>0.9>0.9
CR5>0.9>0.90.85  ± 0.020.76  ± 0.06N.D.0.83  ± 0.04>0.9>0.9>0.90.72  ± 0.07
CR6>0.9>0.9>0.9>0.9N.D.>0.9>0.9>0.9>0.9>0.9

The upper portion of the table refers to receptors expressed in CHO cells, while the rest of the table refers to receptors expressed in COS-7 cells. The data are the means ± S.E.M. from three or more determinations, except for the UH-AH 37 data, which are from two to three determinations. See text for further discussion.

    • N.D., not determined.