Table 2

Effect of SCH-202676 on [125I]EGF binding to A431 cell membranes

Treatment[125I]EGF Specific Bound
cpm
Control12,054  ± 518
10 μM SCH-20267614,551  ± 785

[125I[EGF binding to A431 cell membranes expressing the EGF receptor in absence (control) and presence of 10 μM SCH-202676 was performed as described under Experimental Procedures. Data shown are mean values ± S.E.M. of triplicates.