Xanthine AR Antagonist | A1 | A2A | A2B | A3 |
---|---|---|---|---|
BW-1433 (K I, nM) | 5.8 ± 1.0 | 239 ± 37 | 30.3 ± 10.1 | 12,300 ± 3,660 |
% Occupancy by 100 μM | >99 | >99 | >99 | 89 |
8-SPT (K I, μM) | 3.2 ± 1.2 | 57 ± 4 | 2.2 ± 0.8 | >100 |
% Occupancy by 100 μM | 96 | 64 | 97 | <10 |
Results are the means ± S.E.M. of triplicate radioligand binding experiments each consisting of seven concentrations of inhibitor assayed in triplicate. See Experimental Procedures for details.