Table 1

Tissue-to-plasma concentration ratio (K _p) of [¹⁴C] TEA in wild-type and jvs mice

Tissue	TEA		Carnitine^1-a
Tissue	Wild-type	jvs	Wild-type	jvs
Brain	0.0809 ± 0.0116	0.0392 ± 0.0043^1-150	1.14	0.80^1-150
Lung	5.29 ± 0.38	3.70 ± 0.41^1-150	20.7	9.50^1-150
Heart	0.961 ± 0.084	1.35 ± 0.17	24.4	1.22^1-150
Liver	16.7 ± 2.2	4.55 ± 0.82^1-150	29.5	8.34^1-150
Kidney	9.89 ± 1.16	25.0 ± 4.6^1-160	31.6	10.8^1-150
Spleen	5.90 ± 0.95	2.47 ± 0.26^1-150	31.6	5.07^1-150
Gut	6.32 ± 0.41	5.70 ± 0.83	15.8	5.37^1-150
Testis	0.526 ± 0.073	0.531 ± 0.207	^1-b	^1-b
Muscle	0.843 ± 0.111	0.783 ± 0.334	2.16	0.54^1-150
Fat	1.09 ± 0.25	0.657 ± 0.167	^1-b	^1-b

K _p values were obtained 4 h after intravenous administration of [¹⁴C]TEA at a dose of 8.8 mg/kg in wild-type and jvs mice. Each value represents the mean ± S.E.M. of four or five mice.

↵1-150 , Significantly decreased compared with the wild-type mice by Student's t-test (p < 0.05).
↵1-160 , Significantly increased compared with the wild-type mice by Student's t-test (p < 0.05).
↵1-a Yokogawa et al. (1999).
↵1-b Results are not available.