Effects of sildenafil, organic nitrates, and the PKA inhibitor PKImyr on PDGF (10 ng/ml)-induced DNA synthesis in SMC.
| Compounds | Inhibition of PDGF-Induced DNA Synthesis |
|---|---|
| % | |
| sildenafil (1 μM) | 5 ± 12 |
| sildenafil (30 μM) | 93 ± 152-150 |
| sildenafil (30 μM) + PKImyr (1 μM) | 25 ± 92-160 |
| ISMN (10 μM) | 42 ± 72-150 |
| ISMN (10 μM) + sildenafil (1 μM) | 92 ± 82-150 |
| ISMN (10 μM) + sildenafil (1 μM) + PKImyr (1 μM) | 12 ± 82-160 |
| PETN (3 μM) | 30 ± 62-150 |
| PETN (3 μM) + sildenafil (1 μM) | 87 ± 82-150 |
| PETN (3 μM) + sildenafil (1 μM) +PKImyr (1 μM) | 26 ± 72-160 |