Table 1

Inhibitory constants of selected flavonoids for [3H]LTC4 transport

FlavonoidKi
μM
Myricetin13.3  ± 2.7 (n = 4)
Quercetin8.1  ± 1.7 (n = 4)
Naringenin (+ 3 mM GSH)20.8  ± 6.4 (n = 4)
Kaempferol2.4  ± 1.6 (n = 4)
Apigenin (+ 3 mM GSH)4.9  ± 0.7 (n = 3)

Uptake of [3H]LTC4 (10 to 500 nM) was measured in the presence of various concentrations of the flavonoids indicated. Double-reciprocal plots were generated and K i values were calculated from the apparent K m. Each flavonoid was tested at two different concentrations in at least two independent experiments. Values shown are the mean ± S.D.