Table 1

Potency (IC50, micromolar) of BAY36-7620 in inhibiting the action of glutamate on the wild-type mGlu1 and various chimeric mGlu receptors. For each receptor, the origin of the ECD (from mGlu1, mGlu2, or mGlu5) and the 7TM [from mGlu1, DmGluA, mGlu2, mGlu5, or mGlu1 and mGlu5 (1/5)] are indicated. Data are means ± S.E.M. of at least three independent experiments performed in triplicate. >100 means that no significant inhibition of the Glu-induced IP formation was detected with 100 μM BAY36-7620.

mGlu1mGlu1/DAmGlu1/2mGlu2/1mGlu1/5-DmGlu5/1-CmGlu5/1-F
ECD1112151
7TM1DA21515/1
IC50(μM)0.16 ± 0.01>100>1000.14 ± 0.05>1000.24 ± 0.010.50 ± 0.06