Table 1

The K _i values of tested compounds for [¹²⁵I] I-AB-MECA (0.15 nM) binding to human A₃adenosine receptors and the dissociation rates (k ₋₁) in the absence and presence of the tested compounds (10 μM). The assay was carried out as described underExperimental Procedures. Data shown are the mean ±S.E. from three independent experiments performed in duplicate.

	K_i(nM)	k₋₁ (min⁻¹)
	nM
Control		0.042 ± 0.007
VUF8501	739 ± 146	0.043 ± 0.004
VUF8502	96 ± 26	0.024 ± 0.003^1-150
VUF8503	581 ± 82	0.041 ± 0.011
VUF8504	17.3 ± 1.7	0.022 ± 0.004^1-150
VUF8505	307 ± 99	0.044 ± 0.012
VUF8507	204 ± 42	0.021 ± 0.002^1-150
VUF5455	1680 ± 620	0.024 ± 0.003^1-150
PD81723	N.D.	0.046 ± 0.009
CGS15943	185 ± 37	0.045 ± 0.005

N.D., not determined.
↵1-150 p < 0.05 compared with control (Student's t test).