Table 1

Genes in which disruption produces cDDP resistance

Organism/SpeciesGeneReference
D. discoideum Sphingosine-1-phosphate lyase 1 Li et al., 2000
D. discoideum Similar to human P2Y purine receptor 1 Li et al., 2000
D. discoideum Similar to phosphatidylinositol-4-phosphate 5-kinase from Arabidopsis thaliana Li et al., 2000
D. discoideum Disruption 280 bp upstream of the gene which is 51% similar to the human CAAX prenyl protease gene Li et al., 2000
D. discoideum Unidentified gene in an AT-rich intergenic region Li et al., 2000
D. discoideum Golgi vesicular membrane-golvesin Li et al., 2000
D. discoideum cAMP-specific phosphodiesterase RegA similar toDrosophila melanogaster/dunce gene Li et al., 2000
HamsterRegulatory subunit (RI) of the cAMP-dependent protein kinase (PKA) Liu et al., 1996
ChickenLyn tyrosine kinase Yoshida et al., 2000a
Mousec-Jun transcription factor AP1 Sanchez-Perez and Perona, 1999
S. cerevisiae cAMP-specific phosphodiesterase PDE2 Burger et al., 2000
S. cerevisiae ZDS2 Burger et al., 2000
S. cerevisiae IRX1 high mobility group protein that has been isolated in yeast specifically binds cDDP-DNA adducts Brown et al., 1993
S. cerevisiae PHR1 photolyase Chu, 1994