Lipid | Functional Group | LPA1 | LPA2 | LPA3 | |||
---|---|---|---|---|---|---|---|
EC50 | Emax | EC50 | Emax | EC50 | Emax | ||
nM | |||||||
LPA | 11.7 | 100 | 6.8 | 100 | 262.5 | 100 | |
31143 | Methylene Hydroxy | 7.9 | 161.4 | 116.5 | 104.6 | 321.8 | 106.6 |
31144 | Methylene Hydroxy | >5000 | N.A. | 2645 | N.A. | 4349 | N.A. |
31139 | Carbo Methyl | 18.5 | 66.2 | 29.2 | 91.3 | 1484 | 84.4 |
31180 | Carbo Methyl | 1215 | N.A. | 3461 | N.A. | >5000 | N.A. |
12178 | Methylene Amino | 4.9 | 98.7 | 50.3 | 103.2 | 683.7 | 102.9 |
12048 | Methylene Amino | >5000 | N.A. | 8250 | N.A. | >5000 | N.A. |
12086 | Methyl | 3.4 | 107.6 | 18.3 | 95.2 | 112.6 | 93.4 |
12101 | Methyl | 2900 | N.A. | >5000 | N.A. | >5000 | N.A. |
12109 | Ethyl | 35.8 | 66.8 | 161.9 | 92.6 | 1083 | 83.5 |
12115 | Ethyl | 1580 | N.A. | 4280 | N.A. | 4980 | N.A. |
12098 | Isopropyl | 73.8 | 51 | 799.3 | 85.8 | 3815 | N.A. |
40105 | Isopropyl | >5000 | N.A. | >5000 | N.A. | >5000 | N.A. |
12084 | Benzyl | 38.4 | 23.7 | 268.3 | 97 | 351.4 | 78.7 |
12255 | Benzyl | >5000 | N.A. | >5000 | N.A. | >5000 | N.A. |
N.A., not applicable..