Table 1

Agonist activities of 2-substituted N-oleoyl ethanolamide phosphoric acid compounds

LipidFunctional GroupLPA1LPA2LPA3
EC50EmaxEC50EmaxEC50Emax
nM
LPA11.71006.8100262.5100
31143Methylene Hydroxy7.9161.4116.5104.6321.8106.6
31144Methylene Hydroxy>5000N.A.2645N.A.4349N.A.
31139Carbo Methyl18.566.229.291.3148484.4
31180Carbo Methyl1215N.A.3461N.A.>5000N.A.
12178Methylene Amino4.998.750.3103.2683.7102.9
12048Methylene Amino>5000N.A.8250N.A.>5000N.A.
12086Methyl3.4107.618.395.2112.693.4
12101Methyl2900N.A.>5000N.A.>5000N.A.
12109Ethyl35.866.8161.992.6108383.5
12115Ethyl1580N.A.4280N.A.4980N.A.
12098Isopropyl73.851799.385.83815N.A.
40105Isopropyl>5000N.A.>5000N.A.>5000N.A.
12084Benzyl38.423.7268.397351.478.7
12255Benzyl>5000N.A.>5000N.A.>5000N.A.
  • N.A., not applicable..