EC50 | Maximal Stimulation1-a | |
---|---|---|
nM | % | |
Neurotransmitters | ||
p-Tyramine | 69 ± 9 | 100 |
β-Phenethylamine | 240 ± 71 | 76 ± 16 |
Tryptamine | 310 ± 76 | 90 ± 6 |
(±)-Synephrine | 580 ± 100 | 90 ± 2 |
(±)-Octopamine | 1,300 ± 350 | 100 ± 3 |
m-Tyramine | 5,400 ± 1,200 | 74 ± 3 |
Dopamine | 5,900 ± 2,600 | 48 ± 5 |
5-Hydroxytryptamine | >10,000 | 47 ± 9 |
Drugs | ||
4-Hydroxyamphetamine | 51 ± 12 | 79 ± 2 |
MPTP | 99 ± 11 | 93 ± 7 |
R(−)-amphetamine | 210 ± 44 | 48 ± 7 |
S(+)-amphetamine | 440 ± 10 | 84 ± 3 |
(±)-MDMA | 1,700 ± 1,200 | 65 ± 13 |
↵1-a Values are expressed as percent of stimulation by p-tyramine.
n = 2 to 4 experiments, each performed in duplicate.