Table 3

DEB urine metabolic ratios from the animal groups in Figure 4A

MouseGenotypeDEB4-OH-DEBTotalMR
1fl/fl,CRE−/−,2D6+/−22.88.831.72.6
2fl/fl,CRE−/−,2D6+/−19.67.226.82.7
3fl/fl,CRE−/−,2D6+/−16.07.223.22.2
4fl/fl,CRE−/−,2D6+/−14.85.520.32.7
 MEAN18.37.225.52.6
 S.D.3.71.44.90.2
1fl/fl,CRE+/−,2D6+/−10.42.813.23.7
2fl/fl,CRE+/−,2D6+/−9.72.512.33.8
3fl/fl,CRE+/−,2D6+/−10.13.713.72.8
4fl/fl,CRE+/−,2D6+/−10.22.512.74.1
 MEAN10.12.913.03.6
 S.D.0.30.50.60.6
1fl/fl,CRE−/−,2D6−/−60.52.462.925.1
2fl/fl,CRE−/−,2D6−/−41.73.244.912.8
3fl/fl,CRE−/−,2D6−/−52.63.155.716.9
 MEAN51.62.954.518.3
 S.D.9.50.49.16.2
1fl/fl,CRE+/−,2D6−/−26.20.927.129.2
2fl/fl,CRE+/−,2D6−/−23.00.823.729.8
3fl/fl,CRE+/−,2D6−/−27.20.828.035.3
4fl/fl,CRE+/−,2D6−/−26.70.827.533.8
 MEAN25.80.826.632.0
 S.D.1.90.11.93.0

Animals were dosed with DEB (2.5 mg/kg) and placed in urine metabolic chambers for 24 h. Values from HNF4α-deleted,CYP2D6 humanized mice that are significantly different (p < 0.05) from HNF4α-nondeleted,CYP2D6 humanized mice (see Table 2 for key).