Urinary excretion (0–24 h) of percentage dose as DEB, 4-OH-DEB, and DEB + 4-OH-DEB, together with the metabolic ratio (MR; percentage dose as DEB/percentage dose as 4-OH-DEB) for wild-type (WT), heterozygous CYP2D6 humanized (HT), and homozygousCYP2D6 humanized mice (HM)
| Mouse | DEB | 4-OH-DEB | Total | MR |
|---|---|---|---|---|
| WT-1 | 60.7 | 3.0 | 63.7 | 20.5 |
| WT-2 | 52.2 | 6.5 | 58.7 | 8.0 |
| WT-3 | 70.1 | 9.1 | 79.2 | 7.7 |
| MEAN | 61.0 | 6.2 | 67.2 | 12.1 |
| S.D. | 9.0 | 3.1 | 10.7 | 7.3 |
| HT-1 | 16.9 | 25.5 | 42.4 | 0.7 |
| HT-2 | 15.9 | 17.7 | 33.6 | 0.9 |
| HT-3 | 17.9 | 28.7 | 46.6 | 0.6 |
| MEAN | 16.9 | 24.0 | 40.9 | 0.7 |
| S.D. | 1.0 | 5.7 | 6.6 | 0.2 |
| HM-1 | 8.5 | 17.4 | 25.8 | 0.5 |
| HM-2 | 14.1 | 27.2 | 41.2 | 0.5 |
| HM-3 | 21.2 | 42.2 | 63.4 | 0.5 |
| MEAN | 14.6 | 29.0 | 43.5 | 0.5 |
| S.D. | 6.4 | 12.5 | 18.9 | 0 |