Table 2

Urinary excretion (0–24 h) of percentage dose as DEB, 4-OH-DEB, and DEB + 4-OH-DEB, together with the metabolic ratio (MR; percentage dose as DEB/percentage dose as 4-OH-DEB) for wild-type (WT), heterozygous CYP2D6 humanized (HT), and homozygousCYP2D6 humanized mice (HM)

MouseDEB4-OH-DEBTotalMR
WT-160.73.063.720.5
WT-252.26.558.78.0
WT-370.19.179.27.7
 MEAN61.06.267.212.1
 S.D.9.03.110.77.3
HT-116.925.542.40.7
HT-215.917.733.60.9
HT-317.928.746.60.6
 MEAN16.924.040.90.7
 S.D.1.05.76.60.2
HM-18.517.425.80.5
HM-214.127.241.20.5
HM-321.242.263.40.5
 MEAN14.629.043.50.5
 S.D.6.412.518.90