Table 1

ED50 for tumor size reduction (day 27–32) relative to saline-injected control mice

DrugMock Transfectantsbcl-2 Transfectants
mg/kg
NCS3–4<1
Cisplatin5–105–10
Vincristine0.75–10.75–1

For each treatment group, the ED50 for tumor size reduction (day 27–32) was defined as the drug dose at which the day 27 to 32 mean tumor volume was one half that of the simultaneously saline-injected group. In most cases, the ED50 falls between two actually administered doses; it is therefore expressed as the range of doses in which it falls. See Materials and Methods for further detail.