Inhibition of digoxin transport test set predicted using inhibition of digoxin transport pharmacophore.
| IC50 | ||
|---|---|---|
| Molecule | Observed | Predicted |
| μM | ||
| Fluoxetine | >10 | 220 |
| Procainamide | >10 | 37 |
| Ivermectin | >10 | 3.1 |
| Lovastatin | <10 | 7.5 |
| Tamoxifen | 10–100 | 13 |
| Midazolam | 10–100 | 28 |
| Cortisol | 10–100 | 38 |
| Terfenadine | <10 | 6.9 |
| Erythromycin | 10 | 9.2 |
| FK5062-a | 0.74 | 10 |
| Cyclosporin2-a | 1.3 | 0.9 |
| Ritonavir | 3.8 | 2 |
| PSC8332-a | 0.11 | 2.3 |
| Mitomycin C | >10 | 220 |
| Colchicine | >100 | 7.3 |
| Daunomycin | 10–100 | 6.9 |
| Paclitaxel | >100 | 32 |
| Vinblastine | <10 | 6.3 |
| CP 995422-a | 3.8 | 0.84 |
↵2-a IC50 data previously published in Wandell et al. (1999a).