Table 3

Digoxin transport IC₅₀ predictions with the inhibition of verapamil binding model

Molecule	Observed IC₅₀	Predicted IC₅₀
	μM
Caffeine	>100	1800
S-mephenytoin	>100	4500
Tolbutamide	>100	290
Chlorzoxazone	>100	5200
Morphine	>100	700
Alfentanil^3-b	112	93
Debrisoquine	>100	6600
Sufentanil^3-b	4.2	2700
Fexofenadine	>100	110
Fentanyl^3-b	6.5	1300
Loperamide^3-b	2.7	300
CP 69042^3-a	2.3	69
Indinavir	44	100
Quinidine^3-a	2.2	120
Nelfinavir	1.4	240
Saquinavir	6.5	100
Verapamil^3-a	2.1	–^3-c
Mibefradil	1.2	160
Ketoconazole	1.2	110
CP 12379^3-a	0.7	82
CP 147478^3-a	0.14	10
CP 114769^3-a	0.3	40
CP 117227^3-a	0.074	59
CP 101556^3-a	0.6	73
LY335979^3-a	0.024	130
CP 114416^3-a	0.036	76
CP 100356^3-a	0.114	69

↵3-a IC₅₀ data previously published in Wandell et al. (1999a).
↵3-b IC₅₀ data presented as an abstract by Wandell et al. (1999b).
↵3-c Molecule in the training set.