Table 2

Cytotoxic potency of pharmacophore panel and calibration compounds in HCT 116 and RKO cells with different p53 status

EC50
CompoundRKORKO-E6HCT+/+HCT−/−
μ M
NSC-3029791.8  ± 0.11.4  ± 0.12.7  ± 0.23.2  ± 0.2
DBA7.0  ± 0.66.5  ± 1.13.2  ± 0.13.8  ± 0.1
Δ 12-PGJ2 9.0  ± 0.89.2  ± 1.03.6  ± 0.34.1  ± 0.1
Curcumin12.5  ± 5.914.9  ± 8.59.7  ± 1.18.6  ± 1.3
NSC-156236>60>60>60>60
PGB1 >60>60>60>60
DPTP>60>60>60>60
Etoposide7.3  ± 1.620.0  ± 2.77.8  ± 3.929.0  ± 6.8
Paclitaxel0.004  ± 0.00.004  ± 0.00.004  ± 0.00.005  ± 0.0
MG1150.8  ± 0.00.7  ± 0.00.8  ± 0.00.7  ± 0.0